The article presents the results of a psychological study of persons affected by sleeping sickness in Kalachi village. In particular: the level of stress resistance, the level of aggressiveness and hostility of participants and other psychophysiological indicators were studied. The purpose of this study is to study the psychological state of persons affected by sleeping sickness in the village of Kalachi. The research methods included: a specially developed psychophysiological questionnaire to identify the general psychophysiological state of victims of sleeping sickness; Holmes and Ragé Stress Test; Bassa-Dark Aggressiveness Questionnaire, methods of descriptive statistics. According to the results, it was revealed that many of the studied psychophysiological characteristics were subjected to severe stress, which was not among participants before they experienced the sleeping sickness. The level of stress resistance is reduced, and the level of aggressiveness is out of norm. The value of the study is the dynamics of mental reactions to a given disease during re-infection. Due to the fact that it turned out there is no pattern here, both adult men and young children, people of different nationalities and lifestyles fall asleep. But some villagers never fell asleep at all. Others, however, went through it several times. This study will help create a rehabilitation program for such patients and take preventive measures for those who have not had it yet.