The article analyzes the problem of professional and personal self-determination of high school students, which is becoming quite relevant in modern socio-economic conditions of society development. Scientific research of a psychological and pedagogical orientation is aimed at finding effective ways to solve this multifaceted problem. That is, special attention is paid to the educated educational and cognitive interests of students. Also, on the basis of theoretical and methodological research, experimental work was organized, which consists of 3 stages: identification, formation and generalization. The ascertaining experiment was attended by students of grades 10-11 (48 students) of the I.Altynsarin Gymnasium №49, Taraz. There are 23 students in the experimental group and 25 students in the control group. To obtain data before and after the experiment, the methods of the "Differential diagnostic question" by E.A.Klimov and J.Holland's professional self-determination were used, and the reliability and stability of the results were determined using the Spearman correlation and the Student's T-test of the difference in values. The study yielded positive results.