The relevance of this article is due to the complexity of decision-making in choosing a future profession. Today, the world around us is more changeable than ever and the requirements it dictates for a specialist’s personality are constantly changing, which makes the problem of professional self-determination even more urgent. The purpose of the article is to theoretically reveal and clearly show the degree of influence of various factors on the professional self-determination of high school students in a secondary school. This study was conducted on the basis of theoretical analysis, which included comparative and comparative analysis; The experimental part of the study was carried out using the empirical survey method. As a result of the research work, systematic data on the degree of predominance of certain factors in the professional self-determination of high school students is shown.